The immunocompetence of Schwann cells
نویسندگان
چکیده
منابع مشابه
The immunocompetence of Schwann cells.
Schwann cells are the myelinating glial cells of the peripheral nervous system that support and ensheath axons with myelin to enable rapid saltatory signal propagation in the axon. Immunocompetence, however, has only recently been recognized as an important feature of Schwann cells. An autoimmune response against components of the peripheral nervous system triggers disabling inflammatory neurop...
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Background: The purification of Schwann cells has proven to be a difficult process, with most methods requiring the use of special equipment. However, obtaining a sufficient number and high purity of Schwann cells is an integral aspect in their use for clinical application. Therefore, the aim of this study was to establish a simple and effective protocol for the isolation and purification of Sc...
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Nerves containing numerous Schwann but their satellite Schwann cells appear cells can be found in bone marrow with well stained. Histological, cytological routine histological methods. Thin nerve and ultrastructural characteristics of these bundles and single nerve fibers containcells are described in detail. Blooding Schwann cells can be identified histoforming cells and nerve fibers with thei...
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Background: Spinal cord has a limited capacity to repair therefore, medical interventions are necessary for treatment of injuries. Transplantation of Schwann cells has shown a great promising result for spinal cord injury (SCI). However, harvesting Schwann cell has been limited due to donor morbidity and limited expansion capacity. Furthermore, accessible sources such as bone marrow stem cells ...
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The myelination of axons in peripheral nerves requires precisely coordinated proliferation and differentiation of Schwann cells (SCs). We found that the activity of the mechanistic target of rapamycin complex 1 (mTORC1), a key signaling hub for the regulation of cellular growth and proliferation, is progressively extinguished as SCs differentiate during nerve development. To study the effects o...
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ژورنال
عنوان ژورنال: Muscle & Nerve
سال: 2007
ISSN: 0148-639X
DOI: 10.1002/mus.20893